Nature Communications (Jun 2019)

Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia

  • Liqing Tian,
  • Ying Shao,
  • Stephanie Nance,
  • Jinjun Dang,
  • Beisi Xu,
  • Xiaotu Ma,
  • Yongjin Li,
  • Bensheng Ju,
  • Li Dong,
  • Scott Newman,
  • Xin Zhou,
  • Patrick Schreiner,
  • Elizabeth Tseng,
  • Ting Hon,
  • Meredith Ashby,
  • Chunliang Li,
  • John Easton,
  • Tanja A. Gruber,
  • Jinghui Zhang

DOI
https://doi.org/10.1038/s41467-019-10637-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here, the authors show that IGH-DUX4 translocation occurs on the silenced IGH allele avoiding toxic high-level expression of DUX4 in B-ALL.