Nature Communications (Jun 2019)
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia
- Liqing Tian,
- Ying Shao,
- Stephanie Nance,
- Jinjun Dang,
- Beisi Xu,
- Xiaotu Ma,
- Yongjin Li,
- Bensheng Ju,
- Li Dong,
- Scott Newman,
- Xin Zhou,
- Patrick Schreiner,
- Elizabeth Tseng,
- Ting Hon,
- Meredith Ashby,
- Chunliang Li,
- John Easton,
- Tanja A. Gruber,
- Jinghui Zhang
Affiliations
- Liqing Tian
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Ying Shao
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Stephanie Nance
- Department of Oncology, St. Jude Children’s Research Hospital
- Jinjun Dang
- Department of Oncology, St. Jude Children’s Research Hospital
- Beisi Xu
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Xiaotu Ma
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Yongjin Li
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Bensheng Ju
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Li Dong
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Scott Newman
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Xin Zhou
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Patrick Schreiner
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Elizabeth Tseng
- Pacific Biosciences
- Ting Hon
- Pacific Biosciences
- Meredith Ashby
- Pacific Biosciences
- Chunliang Li
- Department of Tumor Cell Biology, St. Jude Children’s Research Hospital
- John Easton
- Department of Computational Biology, St. Jude Children’s Research Hospital
- Tanja A. Gruber
- Department of Oncology, St. Jude Children’s Research Hospital
- Jinghui Zhang
- Department of Computational Biology, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-019-10637-8
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 10
Abstract
The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here, the authors show that IGH-DUX4 translocation occurs on the silenced IGH allele avoiding toxic high-level expression of DUX4 in B-ALL.
