Characteristic of cellular immunity in children with recurrent respiratory diseases, depending on the level of immunoglobulin E production

Abstract

Purpose. To analyze the indices of cellular immunity in children with recurrent respiratory diseases, depending on the level of IgE production. Materials and Methods. The study of cellular immunity and the level of IgE production in 81 children with recurrent respiratory diseases, aged from 2 to 6 years old (I group – 45 children with IgE index above the reference values of the age norm; II group - 36 children with normal IgE level). Results. In 55.56 % of children with recurrent respiratory diseases, the IgE level has exceeded the reference values of the age norm. Cellular immunity in 53.33 % of children with recurrent respiratory diseases and high IgE levels was significantly more often characterized by decrease in the relative amount of CD3+, CD4+ T-lymphocytes phenotype and increase in the relative values of CD25+ lymphocytes phenotype with a moderate positive direct correlation between CD25+ lymphocytes and IgE levels (R = 0.35, p < 0.05). In children with recurrent respiratory diseases and normal IgE levels the relative amount of СD3+, CD4+, CD8+ lymphocytes phenotype was decreased and increased CD16+, CD19+ phenotypes in 38.89 %, and increase in the relative values of CD25+ lymphocytes phenotype in 11.1 %. Regardless of the ability to IgE production the cellular immunity parameters within the age standard were recorded in 53.09 % of the examined children and violation of the cellular immunity was observed in 46.91 % of cases. Conclusions. In children with recurrent respiratory diseases changes in the cellular immunity were registered 14.44 % more often in the group of children with high IgE level.

Keywords

• cellular immunity
• recurrency
• respiratory tract infections
• immunoglobulin E
• children