Nature Communications (Aug 2020)
Wnt activation as a therapeutic strategy in medulloblastoma
- Branavan Manoranjan,
- Chitra Venugopal,
- David Bakhshinyan,
- Ashley A. Adile,
- Laura Richards,
- Michelle M. Kameda-Smith,
- Owen Whitley,
- Anna Dvorkin-Gheva,
- Minomi Subapanditha,
- Neil Savage,
- Nazanin Tatari,
- Dillon McKenna,
- Blessing Bassey-Archibong,
- Neil Winegarden,
- Robin Hallett,
- John P. Provias,
- Blake Yarascavitch,
- Olufemi Ajani,
- Adam Fleming,
- Gary D. Bader,
- Trevor J. Pugh,
- Bradley W. Doble,
- Sheila K. Singh
Affiliations
- Branavan Manoranjan
- Section of Neurosurgery, Department of Clinical Neurosciences, University of Calgary
- Chitra Venugopal
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- David Bakhshinyan
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Ashley A. Adile
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Laura Richards
- Princess Margaret Cancer Centre, University Health Network
- Michelle M. Kameda-Smith
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Owen Whitley
- Department of Molecular Genetics, University of Toronto
- Anna Dvorkin-Gheva
- Department of Pathology, Faculty of Health Sciences, McMaster University
- Minomi Subapanditha
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Neil Savage
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Nazanin Tatari
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Dillon McKenna
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Blessing Bassey-Archibong
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Neil Winegarden
- Princess Margaret Cancer Centre, University Health Network
- Robin Hallett
- Northern Biologics
- John P. Provias
- Department of Pathology, Faculty of Health Sciences, McMaster University
- Blake Yarascavitch
- Department of Surgery, Faculty of Health Sciences, McMaster University
- Olufemi Ajani
- Department of Surgery, Faculty of Health Sciences, McMaster University
- Adam Fleming
- Department of Pediatrics, Faculty of Health Sciences, McMaster University
- Gary D. Bader
- Department of Molecular Genetics, University of Toronto
- Trevor J. Pugh
- Princess Margaret Cancer Centre, University Health Network
- Bradley W. Doble
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- Sheila K. Singh
- McMaster Stem Cell and Cancer Research Institute, McMaster University
- DOI
- https://doi.org/10.1038/s41467-020-17953-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
The Wnt molecular subgroup of medulloblastoma is associated with better prognosis than the other molecular subgroups. Here, the authors show that activating Wnt signaling impairs tumor development and improves survival in Group 3 and Group 4 medulloblastoma preclinical models.
