Day 3 versus day 5 embryo freezing: which is better, A comparative study

Abstract

Background: Freezing of embryos and gametes is considered one of the corner stones of ART. Its application increases both IVF safety and efficiency. Aim and objectives: the aim of the present study is to compare cleaved embryo and blastocyst freezing to determine the optimal time for embryo cryopreservation, Subjects and methods: A randomized clinical trial, it was involved 300 cases of infertile patients who will undergo ICSI cycles and embryo freezing at the assisted reproduction unit, Qena University hospital, South Valley University, Egypt after complete infertility evaluation. Population was divided into two groups: Group 1 (n =150), underwent embryo freezing at day 3 then will undergo FET (Cleaved embryo). Group 2 (n =150), will underwent embryo freezing at day 5 then will undergo FET (Blastocyst) The duration of the study had been from 6 to 12 months, Results: the results revealed that there is high significant difference between the studied groups as regard Total number of survival more survival was observed in blastocyst group, while there is no significant difference between the studied groups as regard completed transfer. Conclusion: The maintenance of embryo culture until day 5 may be a more sensible approach for the correct identification of best quality embryos with the highest probability of success for both transfer and freezing.

Keywords

• embryo; blastocyst; transfer; intra-cytoplasmic sperm injection