Антибиотики и Химиотерапия (May 2020)

Cycloferon Efficacy of Therapy of Chronic Hepatitis B (Results of Randomized Multicentre Study)

  • T. V. Sologub,
  • A. A. Shuldyakov,
  • L. G. Goryacheva,
  • I. P. Baranova,
  • YU. N. Linkova,
  • A. L. Kovalenko,
  • M. G. Romantsov

Journal volume & issue
Vol. 55, no. 9-10
pp. 37 – 41

Abstract

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The best therapeutic effect in the treatment of patients with chronic hepatitis B was observed with the use of cycloferon in the scheme of the antiviral therapy. The combination of cycloferon with lamivudine provided complete stable remission in 54.1% of the patients, whereas the use of а-interferon in combination with cycloferon provided remission in 44.1% of the lamivudine-resistant patients. The use of cycloferon in the therapy of chronic hepatitis B made it possible to lower the frequency and manifestation level of the side effects and prevented the lamivudine resistance development and generation of the virus mutants.

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