Targeting WNT Signaling for Multifaceted Glioblastoma Therapy

Matthew McCord; Yoh-suke Mukouyama; Mark R. Gilbert; Sadhana Jackson

doi:10.3389/fncel.2017.00318

Frontiers in Cellular Neuroscience (Oct 2017)

Targeting WNT Signaling for Multifaceted Glioblastoma Therapy

Matthew McCord,
Yoh-suke Mukouyama,
Mark R. Gilbert,
Sadhana Jackson

Affiliations

Matthew McCord: Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, United States
Yoh-suke Mukouyama: Laboratory of Stem Cell and Neuro-Vascular Biology, Genetic and Developmental Biology Center, National Heart, Lung and Blood Institute, Bethesda, MD, United States
Mark R. Gilbert: Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, United States
Sadhana Jackson: Neuro-Oncology Branch, National Cancer Institute, Bethesda, MD, United States

DOI: https://doi.org/10.3389/fncel.2017.00318
Journal volume & issue: Vol. 11

Abstract

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The WNT signaling pathway has been of great interest to developmental biologists for decades and has more recently become a central topic for study in cancer biology. It is vital for cell growth and regulation of embryogenesis in many organ systems, particularly the CNS and its associated vasculature. We summarize the role of WNT in CNS development and describe how WNT signaling makes key contributions to malignant glioma stemness, invasiveness, therapeutic resistance, and angiogenesis. The role of WNT in these mechanisms, along with creation and maintainance of the blood-brain barrier (BBB), points to the potential of WNT as a multi-faceted target in malignant glioma therapy.

Published in Frontiers in Cellular Neuroscience

ISSN: 1662-5102 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/cellular-neuroscience

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