Journal of Diabetes Investigation (Jan 2022)

Prevalence and clinical characteristics of fulminant type 1 diabetes mellitus in Korean adults: A multi‐institutional joint research

  • Sun Ok Song,
  • Jae‐Seung Yun,
  • Seung‐Hyun Ko,
  • Yu‐Bae Ahn,
  • Bo‐Yeon Kim,
  • Chul‐Hee Kim,
  • Ja Young Jeon,
  • Dae Jung Kim,
  • Da Hae Seo,
  • So Hun Kim,
  • Jung Hyun Noh,
  • Da Young Lee,
  • Kyung‐Soo Kim,
  • Soo‐Kyung Kim,
  • the Type 1 Diabetes Study Group of Gyeonggi‐Incheon Branch of the Korean Diabetes Association

DOI
https://doi.org/10.1111/jdi.13638
Journal volume & issue
Vol. 13, no. 1
pp. 47 – 53

Abstract

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Abstract Aims/Introduction We aimed to determine the hospital‐based prevalence and clinical features of fulminant type 1 diabetes mellitus in Korea. Materials and Methods We identified all patients with diabetes who regularly visited the Endocrinology outpatient clinics at eight centers for a period >1 year between January 2012 and June 2017. We investigated their medical records retrospectively. Results During this period, 76,309 patients with diabetes had been regularly followed up. Among them, 913 (1.2%) patients had type 1 diabetes mellitus . There were 462 patients with type 1 diabetes mellitus whose data at the time of the first diagnosis could be identified (359 and 103 with non‐ketosis and ketosis onset, respectively). Of these, 15 (3.2% of type 1 diabetes mellitus, 14.6% of ketosis onset diabetes) patients had fulminant type 1 diabetes mellitus. The median ages at diagnosis were 40 and 27 years in the fulminant type 1 diabetes mellitus and non‐fulminant type 1 diabetes mellitus groups, respectively. The patients with fulminant type 1 diabetes mellitus had higher body mass index, lower glycated hemoglobin and fasting/peak C‐peptide, and lower frequent glutamic acid decarboxylase antibody‐positive rate (P =0.0010) at diagnosis. Furthermore, they had lower glycated hemoglobin at the last follow‐up examination than those with non‐fulminant type 1 diabetes mellitus. Conclusions In this study, the prevalence of type 1 diabetes mellitus was 1.2% among all patients with diabetes, and that of fulminant type 1 diabetes mellitus was 3.2% among those newly diagnosed with type 1 diabetes mellitus. The glycated hemoglobin levels were lower in patients with fulminant type 1 diabetes mellitus than in those with non‐fulminant type 1 diabetes mellitus at diagnosis and at the last follow‐up examination.

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