Frontiers in Immunology (Jan 2023)
IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study
- Maryam Shojaei,
- Maryam Shojaei,
- Maryam Shojaei,
- Amir Shamshirian,
- James Monkman,
- Laura Grice,
- Laura Grice,
- Minh Tran,
- Chin Wee Tan,
- Chin Wee Tan,
- Siok Min Teo,
- Gustavo Rodrigues Rossi,
- Timothy R. McCulloch,
- Marek Nalos,
- Maedeh Raei,
- Alireza Razavi,
- Roya Ghasemian,
- Mobina Gheibi,
- Fatemeh Roozbeh,
- Peter D. Sly,
- Kirsten M. Spann,
- Keng Yih Chew,
- Yanshan Zhu,
- Yao Xia,
- Timothy J. Wells,
- Alexandra Cristina Senegaglia,
- Alexandra Cristina Senegaglia,
- Carmen Lúcia Kuniyoshi,
- Carmen Lúcia Kuniyoshi,
- Claudio Luciano Franck,
- Anna Flavia Ribeiro dos Santos,
- Lucia de Noronha,
- Sepideh Motamen,
- Reza Valadan,
- Reza Valadan,
- Omolbanin Amjadi,
- Rajan Gogna,
- Rajan Gogna,
- Esha Madan,
- Reza Alizadeh-Navaei,
- Liliana Lamperti,
- Felipe Zuñiga,
- Estefania Nova-Lamperti,
- Gonzalo Labarca,
- Gonzalo Labarca,
- Ben Knippenberg,
- Velma Herwanto,
- Ya Wang,
- Ya Wang,
- Ya Wang,
- Amy Phu,
- Amy Phu,
- Tracy Chew,
- Timothy Kwan,
- Karan Kim,
- Sally Teoh,
- Tiana M. Pelaia,
- Win Sen Kuan,
- Win Sen Kuan,
- Yvette Jee,
- Jon Iredell,
- Jon Iredell,
- Jon Iredell,
- Ken O’Byrne,
- John F. Fraser,
- Melissa J. Davis,
- Melissa J. Davis,
- Melissa J. Davis,
- Gabrielle T. Belz,
- Majid E. Warkiani,
- Carlos Salomon Gallo,
- Carlos Salomon Gallo,
- Fernando Souza-Fonseca-Guimaraes,
- Quan Nguyen,
- Anthony Mclean,
- Arutha Kulasinghe,
- Kirsty R. Short,
- Benjamin Tang,
- Benjamin Tang
Affiliations
- Maryam Shojaei
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Maryam Shojaei
- Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia
- Maryam Shojaei
- Department of Medicine, Sydney Medical School Nepean, Nepean Hospital, University of Sydney, Penrith, NSW, Australia
- Amir Shamshirian
- Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
- James Monkman
- Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
- Laura Grice
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
- Laura Grice
- School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, Australia
- Minh Tran
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
- Chin Wee Tan
- The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia
- Chin Wee Tan
- Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia
- Siok Min Teo
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
- Gustavo Rodrigues Rossi
- Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
- Timothy R. McCulloch
- Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
- Marek Nalos
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Maedeh Raei
- Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
- Alireza Razavi
- 0Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
- Roya Ghasemian
- 1Antimicrobial Resistance Research Centre, Department of Infectious Diseases, Mazandaran University of Medical Sciences, Sari, Iran
- Mobina Gheibi
- 2Student Research Committee, School of Allied Medical Sciences, Mazandaran University of Medical Science, Sari, Iran
- Fatemeh Roozbeh
- 3Mazandaran University of Medical Sciences, Sari, Iran
- Peter D. Sly
- 4Child Health Research Centre, The University of Queensland, South Brisbane, QLD, Australia
- Kirsten M. Spann
- 5Centre for Immunology and Infection Control, Faculty of Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia
- Keng Yih Chew
- 6School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia
- Yanshan Zhu
- 6School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia
- Yao Xia
- 7School of Science, Edith Cowan University; School of Biomedical Science, University of Western Australia, Perth, WA, Australia
- Timothy J. Wells
- Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
- Alexandra Cristina Senegaglia
- 8Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil
- Alexandra Cristina Senegaglia
- 9Core for Cell Technology, School of Medicine, PontifìciaUniversidade Católica do Paraná, Curitiba, Brazil
- Carmen Lúcia Kuniyoshi
- 8Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil
- Carmen Lúcia Kuniyoshi
- 9Core for Cell Technology, School of Medicine, PontifìciaUniversidade Católica do Paraná, Curitiba, Brazil
- Claudio Luciano Franck
- 8Complexo Hospital de Clinicas, Universidade Federal do Paraná, Curitiba, Brazil
- Anna Flavia Ribeiro dos Santos
- 0Pontifical Catholic University of Parana, Curitiba, Brazil
- Lucia de Noronha
- 0Pontifical Catholic University of Parana, Curitiba, Brazil
- Sepideh Motamen
- 1Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
- Reza Valadan
- 2Molecular and Cell Biology Research Centre, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
- Reza Valadan
- 3Department of Immunology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
- Omolbanin Amjadi
- Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
- Rajan Gogna
- 4Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark
- Rajan Gogna
- 5Novo Nordisk Foundation centre for Stem Cell Biology, DanStem, Faculty of Health and Medical Sciences, Champalimaud Centre for the Unknown, Lisbon, Portugal
- Esha Madan
- 6Campania Centre for the Unknown, Lisbon, Portugal
- Reza Alizadeh-Navaei
- Gastrointestinal Cancer Research Centre, Non-Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
- Liliana Lamperti
- 7Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile
- Felipe Zuñiga
- 8Molecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile
- Estefania Nova-Lamperti
- 8Molecular and Translational Immunology Laboratory, Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, Universidad de Concepcion, Concepcion, Chile
- Gonzalo Labarca
- 7Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile
- Gonzalo Labarca
- 9Faculty of Medicine, Universidad de Concepcion, Concepcion, Chile
- Ben Knippenberg
- 0Infectious Diseases Department, Royal Darwin Hospital, Darwin, NT, Australia
- Velma Herwanto
- 1Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia
- Ya Wang
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Ya Wang
- Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia
- Ya Wang
- Department of Medicine, Sydney Medical School Nepean, Nepean Hospital, University of Sydney, Penrith, NSW, Australia
- Amy Phu
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Amy Phu
- 2Westmead Clinical School, Sydney Medical School, University of Sydney, Sydney, NSW, Australia
- Tracy Chew
- 3Sydney Informatics Hub, Core Research Facilities, University of Sydney, Sydney, NSW, Australia
- Timothy Kwan
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Karan Kim
- Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia
- Sally Teoh
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Tiana M. Pelaia
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Win Sen Kuan
- 4Emergency Medicine Department, National University Hospital, National University Health System, Singapore, Singapore
- Win Sen Kuan
- 5Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
- Yvette Jee
- 4Emergency Medicine Department, National University Hospital, National University Health System, Singapore, Singapore
- Jon Iredell
- 6Faculty of Medicine and Health, School of Medical Sciences, University of Sydney, Sydney, NSW, Australia
- Jon Iredell
- 7Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Sydney, NSW, Australia
- Jon Iredell
- 8Westmead Hospital, Western Sydney Local Health District, Sydney, NSW, Australia
- Ken O’Byrne
- 9Queensland University of Technology, Centre for Genomics and PersonalisedHealth, School of Biomedical Sciences, Brisbane, QLD, Australia
- John F. Fraser
- 0Critical Care Research Group, The University of Queensland, Brisbane, QLD, Australia
- Melissa J. Davis
- The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC, Australia
- Melissa J. Davis
- Department of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia
- Melissa J. Davis
- 1Department of Clinical Pathology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia
- Gabrielle T. Belz
- Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
- Majid E. Warkiani
- 2Australia Centre for Health Technologies (CHT) & Institute for Biomedical Materials & Devices (IBMD), School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia
- Carlos Salomon Gallo
- 7Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepcion, Concepcion, Chile
- Carlos Salomon Gallo
- 3Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, QLD, Australia
- Fernando Souza-Fonseca-Guimaraes
- Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
- Quan Nguyen
- Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia
- Anthony Mclean
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Arutha Kulasinghe
- Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia
- Kirsty R. Short
- 6School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia
- Benjamin Tang
- Department of Intensive Care Medicine, Nepean Hospital, Penrith, NSW, Australia
- Benjamin Tang
- Centre for Immunology and Allergy Research, the Westmead Institute for Medical Research, Westmead, NSW, Australia
- DOI
- https://doi.org/10.3389/fimmu.2022.1060438
- Journal volume & issue
-
Vol. 13
Abstract
PurposeRobust biomarkers that predict disease outcomes amongst COVID-19 patients are necessary for both patient triage and resource prioritisation. Numerous candidate biomarkers have been proposed for COVID-19. However, at present, there is no consensus on the best diagnostic approach to predict outcomes in infected patients. Moreover, it is not clear whether such tools would apply to other potentially pandemic pathogens and therefore of use as stockpile for future pandemic preparedness.MethodsWe conducted a multi-cohort observational study to investigate the biology and the prognostic role of interferon alpha-inducible protein 27 (IFI27) in COVID-19 patients.ResultsWe show that IFI27 is expressed in the respiratory tract of COVID-19 patients and elevated IFI27 expression in the lower respiratory tract is associated with the presence of a high viral load. We further demonstrate that the systemic host response, as measured by blood IFI27 expression, is associated with COVID-19 infection. For clinical outcome prediction (e.g., respiratory failure), IFI27 expression displays a high sensitivity (0.95) and specificity (0.83), outperforming other known predictors of COVID-19 outcomes. Furthermore, IFI27 is upregulated in the blood of infected patients in response to other respiratory viruses. For example, in the pandemic H1N1/09 influenza virus infection, IFI27-like genes were highly upregulated in the blood samples of severely infected patients.ConclusionThese data suggest that prognostic biomarkers targeting the family of IFI27 genes could potentially supplement conventional diagnostic tools in future virus pandemics, independent of whether such pandemics are caused by a coronavirus, an influenza virus or another as yet-to-be discovered respiratory virus.
Keywords
