Nanocurcumin-Based Sugar-Free Formulation: Development and Impact on Diabetes and Oxidative Stress Reduction
Safa Ferradj,
Madiha Melha Yahoum,
Mounia Rebiha,
Ikram Nabi,
Selma Toumi,
Sonia Lefnaoui,
Amel Hadj-Ziane-Zafour,
Nabil Touzout,
Hichem Tahraoui,
Adil Mihoub,
Mahmoud F. Seleiman,
Nawab Ali,
Jie Zhang,
Abdeltif Amrane
Affiliations
Safa Ferradj
Laboratory of Chemical Engineering, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria
Madiha Melha Yahoum
Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau Pôle Urbain, Medea University, Medea 26000, Algeria
Mounia Rebiha
Functional Analysis of Chemical Processes Laboratory, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria
Ikram Nabi
Laboratory of Chemical Engineering, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria
Selma Toumi
Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau Pôle Urbain, Medea University, Medea 26000, Algeria
Sonia Lefnaoui
Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau Pôle Urbain, Medea University, Medea 26000, Algeria
Amel Hadj-Ziane-Zafour
Laboratory of Chemical Engineering, Chemical Engineering Department, Saad Dahlab University, Blida 09000, Algeria
Nabil Touzout
Department of Nature and Life Sciences, Faculty of Sciences, Pole Urban Ouzera, University of Medea, Medea 26000, Algeria
Hichem Tahraoui
Laboratory of Biomaterials and Transport Phenomena (LBMPT), Nouveau Pôle Urbain, Medea University, Medea 26000, Algeria
Adil Mihoub
Biophysical Environment Station, Center for Scientific and Technical Research on Arid Regions, Touggourt 30000, Algeria
Mahmoud F. Seleiman
Department of Plant Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia
Nawab Ali
Department of Biosystems and Agricultural Engineering (BAE), College of Agriculture and Natural Resources, Michigan State University, East Lansing, MI 48824, USA
Jie Zhang
School of Engineering, Merz Court, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
Abdeltif Amrane
National High School of Chemistry of Rennes, Scientific Research National Center (CNRS), ISCR—UMR 6226, Rennes University, F-35000 Rennes, France
The objective of this study is the development of innovative nanocurcumin-based formulations designed for the treatment and prevention of oxidative stress and diabetes. Nanocurcumin was obtained through a micronization process and subsequently encapsulated within biopolymers derived from corn starch and fenugreek mucilage, achieving encapsulation rates of 75% and 85%, respectively. Subsequently, the encapsulated nanocurcumin was utilized in the formulation of sugar-free syrups based on Stevia rebaudiana Bertoni. The stability of the resulting formulations was assessed by monitoring particle size distribution and zeta potential over a 25-day period. Dynamic light scattering (DLS) revealed a particle size of 119.9 nm for the fenugreek mucilage-based syrup (CURF) and 117 nm for the corn starch-based syrup (CURA), with polydispersity indices PDIs of 0.509 and 0.495, respectively. The dissolution rates of the encapsulated nanocurcumin were significantly enhanced, showing a 67% improvement in CURA and a 70% enhancement in CURF compared with crude curcumin (12.82%). Both formulations demonstrated excellent antioxidant activity, as evidenced by polyphenol quantification using the 2.2-diphenyl 1-pycrilhydrazyl (DPPH) assay. In the evaluation of antidiabetic activity conducted on Wistar rats, a substantial reduction in fasting blood sugar levels from 392 to 187 mg/mL was observed. The antioxidant properties of CURF in reducing oxidative stress were clearly demonstrated by a macroscopic observation of the rats’ livers, including their color and appearance.
