Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan

Yoshiyuki Suzuki; Yen Hai Doan; Hirokazu Kimura; Hiroto Shinomiya; Komei Shirabe; Kazuhiko Katayama

doi:10.3389/fmicb.2019.00116

Frontiers in Microbiology (Feb 2019)

Predicting Directions of Changes in Genotype Proportions Between Norovirus Seasons in Japan

Yoshiyuki Suzuki,
Yen Hai Doan,
Hirokazu Kimura,
Hiroto Shinomiya,
Komei Shirabe,
Kazuhiko Katayama

Affiliations

Yoshiyuki Suzuki: Graduate School of Natural Sciences, Nagoya City University, Nagoya, Japan
Yen Hai Doan: Department of Virology II, National Institute of Infectious Diseases, Musashimurayama, Japan
Hirokazu Kimura: Graduate School of Health Science, Gunma Paz University, Takasaki, Japan
Hiroto Shinomiya: Department of Microbiology, Ehime Prefecctural Institute of Public Health and Environmental Science, Matsuyama, Japan
Komei Shirabe: Division of Virology, Yamaguchi Prefectural Institute of Public Health and Environment, Yamaguchi, Japan
Kazuhiko Katayama: Kitasato Institute for Life Sciences, Kitasato University, Minato, Japan

DOI: https://doi.org/10.3389/fmicb.2019.00116
Journal volume & issue: Vol. 10

Abstract

Read online

The norovirus forecasting system (NOROCAST) has been developed for predicting directions of changes in genotype proportions between human norovirus (HuNoV) seasons in Japan through modeling herd immunity to structural protein 1 (VP1). Here 404 nearly complete genomic sequences of HuNoV were analyzed to examine whether the performance of NOROCAST could be improved by modeling herd immunity to VP2 and non-structural proteins (NS) in addition to VP1. It was found that the applicability of NOROCAST may be extended by compensating for unavailable sequence data and observed genotype proportions of 0 in each season. Incorporation of herd immunity to VP2 and NS did not appear to improve the performance of NOROCAST, suggesting that VP1 may be a suitable target of vaccines.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

Abstract

Keywords