Communications Biology (Mar 2023)

Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences

  • Kyle A. Campbell,
  • Justin A. Colacino,
  • Muraly Puttabyatappa,
  • John F. Dou,
  • Elana R. Elkin,
  • Saher S. Hammoud,
  • Steven E. Domino,
  • Dana C. Dolinoy,
  • Jaclyn M. Goodrich,
  • Rita Loch-Caruso,
  • Vasantha Padmanabhan,
  • Kelly M. Bakulski

DOI
https://doi.org/10.1038/s42003-023-04623-6
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 15

Abstract

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A single-cell RNA-seq analysis of placental villous tissue provides a deconvolution reference atlas of fetal and maternal placental cell types, and indicates that placental cellular heterogeneity in preeclampsia might contribute to differences in bulk gene expression.