Nature Communications (Oct 2017)

Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV

  • Ann-Muriel Steff,
  • James Monroe,
  • Kristian Friedrich,
  • Sumana Chandramouli,
  • Thi Lien-Anh Nguyen,
  • Sai Tian,
  • Sarah Vandepaer,
  • Jean-François Toussaint,
  • Andrea Carfi

DOI
https://doi.org/10.1038/s41467-017-01092-4
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Boosting of maternal antibodies against RSV is a potential approach to protect infants from severe infection, but data from animal models is missing. Here Steff et al. test two different boosts in seropositive cattle pre-exposed to bovine RSV and show that pre-fusion F strongly boosts neutralizing responses.