The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

Wing K. Man; Bogachan Tahirbegi; Michail D. Vrettas; Swapan Preet; Liming Ying; Michele Vendruscolo; Alfonso De Simone; Giuliana Fusco

doi:10.1038/s41467-021-21027-4

Nature Communications (Feb 2021)

The docking of synaptic vesicles on the presynaptic membrane induced by α-synuclein is modulated by lipid composition

Wing K. Man,
Bogachan Tahirbegi,
Michail D. Vrettas,
Swapan Preet,
Liming Ying,
Michele Vendruscolo,
Alfonso De Simone,
Giuliana Fusco

Affiliations

Wing K. Man: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Bogachan Tahirbegi: Department of Chemistry, Imperial College London, Molecular Sciences Research Hub, White City Campus
Michail D. Vrettas: Department of Pharmacy, University of Naples “Federico II”
Swapan Preet: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Liming Ying: National Heart and Lung Institute, Imperial College London, Molecular Sciences Research Hub, White City Campus
Michele Vendruscolo: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge
Alfonso De Simone: Department of Pharmacy, University of Naples “Federico II”
Giuliana Fusco: Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge

DOI: https://doi.org/10.1038/s41467-021-21027-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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α-Synuclein is a presynaptic protein whose aberrant aggregation is associated with Parkinson’s disease. Here, the authors show how αSynuclein-induced docking of synaptic vesicles is modulated by the lipid composition changes typically observed in neurodegeneration using an in vitro system.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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