Communications Biology (Sep 2021)

CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis

  • Chahat Mehra,
  • Ji-Hyun Chung,
  • Yi He,
  • Mónica Lara-Márquez,
  • Marie-Anne Goyette,
  • Nadia Boufaied,
  • Véronique Barrès,
  • Véronique Ouellet,
  • Karl-Phillippe Guérard,
  • Carine Delliaux,
  • Fred Saad,
  • Jacques Lapointe,
  • Jean-François Côté,
  • David P. Labbé,
  • Nathalie Lamarche-Vane

DOI
https://doi.org/10.1038/s42003-021-02520-4
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Mehra et al. investigate the role of CdGAP in early biochemical recurrence and bone metastasis in prostate cancer. The authors find that knocking down CdGAP leads to reduced cell motility, invasion and proliferation in PC-3 and 22Rv1 cells while orthotopic injection of CdGAP-depleted PC-3 cells reduces distant metastatic burden.