Nature Communications (Sep 2018)
Cerebello-thalamo-cortical hyperconnectivity as a state-independent functional neural signature for psychosis prediction and characterization
- Hengyi Cao,
- Oliver Y. Chén,
- Yoonho Chung,
- Jennifer K. Forsyth,
- Sarah C. McEwen,
- Dylan G. Gee,
- Carrie E. Bearden,
- Jean Addington,
- Bradley Goodyear,
- Kristin S. Cadenhead,
- Heline Mirzakhanian,
- Barbara A. Cornblatt,
- Ricardo E. Carrión,
- Daniel H. Mathalon,
- Thomas H. McGlashan,
- Diana O. Perkins,
- Aysenil Belger,
- Larry J. Seidman,
- Heidi Thermenos,
- Ming T. Tsuang,
- Theo G. M. van Erp,
- Elaine F. Walker,
- Stephan Hamann,
- Alan Anticevic,
- Scott W. Woods,
- Tyrone D. Cannon
Affiliations
- Hengyi Cao
- Department of Psychology, Yale University
- Oliver Y. Chén
- Department of Psychology, Yale University
- Yoonho Chung
- Department of Psychology, Yale University
- Jennifer K. Forsyth
- Department of Psychology, University of California Los Angeles
- Sarah C. McEwen
- Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles
- Dylan G. Gee
- Department of Psychology, Yale University
- Carrie E. Bearden
- Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles
- Jean Addington
- Department of Psychiatry, University of Calgary
- Bradley Goodyear
- Departments of Radiology, Clinical Neuroscience and Psychiatry, University of Calgary
- Kristin S. Cadenhead
- Department of Psychiatry, University of California San Diego
- Heline Mirzakhanian
- Department of Psychiatry, University of California San Diego
- Barbara A. Cornblatt
- Department of Psychiatry Research, Zucker Hillside Hospital
- Ricardo E. Carrión
- Department of Psychiatry Research, Zucker Hillside Hospital
- Daniel H. Mathalon
- Department of Psychiatry, University of California San Francisco
- Thomas H. McGlashan
- Department of Psychiatry, Yale University
- Diana O. Perkins
- Department of Psychiatry, University of North Carolina
- Aysenil Belger
- Department of Psychiatry, University of North Carolina
- Larry J. Seidman
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School
- Heidi Thermenos
- Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School
- Ming T. Tsuang
- Department of Psychiatry, University of California San Diego
- Theo G. M. van Erp
- Department of Psychiatry and Human Behavior, University of California Irvine
- Elaine F. Walker
- Department of Psychology, Emory University
- Stephan Hamann
- Department of Psychology, Emory University
- Alan Anticevic
- Department of Psychiatry, Yale University
- Scott W. Woods
- Department of Psychiatry, Yale University
- Tyrone D. Cannon
- Department of Psychology, Yale University
- DOI
- https://doi.org/10.1038/s41467-018-06350-7
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Brain function alterations in schizophrenia and other psychotic disorders remain poorly understood. Here, the authors discover that increased neural connectivity in the cerebello-thalamo-cortical circuitry predicts psychosis in those at high risk, and is present in people with schizophrenia.
