Annals of Internal Medicine: Clinical Cases (Dec 2023)

Unusual Extra-intestinal Manifestations of Crohn Disease Complicated by Incidentally Diagnosed Pancreatic Neuroendocrine Tumor

  • Collin Mayemura,
  • Sergei Tatishchev,
  • Florence-Damilola Odufalu,
  • Sarah Sheibani,
  • Cynthia Cherfane,
  • Bing Zhang

DOI
https://doi.org/10.7326/aimcc.2023.0851
Journal volume & issue
Vol. 2, no. 12

Abstract

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Crohn disease is associated with nonnecrotizing epithelioid granulomas, which rarely involve extra-intestinal solid organs. Management of moderate-to-severe Crohn disease, especially with extra-intestinal manifestations, relies on biologic therapies and small molecules which suppress the immune system and potentially increase cancer risk. We present the diagnosis and management of a rare case of Crohn disease with nonnecrotizing epithelioid granulomas in the sacral spine, pancreas, and peripancreatic soft tissue, complicated by an incidentally diagnosed pancreatic neuroendocrine tumor.