Nature Communications (May 2021)
Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features
- Hitoshi Dejima,
- Xin Hu,
- Runzhe Chen,
- Jiexin Zhang,
- Junya Fujimoto,
- Edwin R. Parra,
- Cara Haymaker,
- Shawna M. Hubert,
- Dzifa Duose,
- Luisa M. Solis,
- Dan Su,
- Junya Fukuoka,
- Kazuhiro Tabata,
- Hoa H. N. Pham,
- Nicholas Mcgranahan,
- Baili Zhang,
- Jie Ye,
- Lisha Ying,
- Latasha Little,
- Curtis Gumbs,
- Chi-Wan Chow,
- Marcos Roberto Estecio,
- Myrna C. B. Godoy,
- Mara B. Antonoff,
- Boris Sepesi,
- Harvey I. Pass,
- Carmen Behrens,
- Jianhua Zhang,
- Ara A. Vaporciyan,
- John V. Heymach,
- Paul Scheet,
- J. Jack Lee,
- Jia Wu,
- P. Andrew Futreal,
- Alexandre Reuben,
- Humam Kadara,
- Ignacio I. Wistuba,
- Jianjun Zhang
Affiliations
- Hitoshi Dejima
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Xin Hu
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Runzhe Chen
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Jiexin Zhang
- Department of Bioinformatics & Computational Biology, the University of Texas MD Anderson Cancer Center
- Junya Fujimoto
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Edwin R. Parra
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Cara Haymaker
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Shawna M. Hubert
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Dzifa Duose
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Luisa M. Solis
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Dan Su
- Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences
- Junya Fukuoka
- Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences
- Kazuhiro Tabata
- Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences
- Hoa H. N. Pham
- Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences
- Nicholas Mcgranahan
- Cancer Research United Kingdom-University College London Lung Cancer Centre of Excellence
- Baili Zhang
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Jie Ye
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Lisha Ying
- Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences
- Latasha Little
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Curtis Gumbs
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Chi-Wan Chow
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Marcos Roberto Estecio
- Department of Epigenetics and Molecular Carcinogenesis, the University of Texas MD Anderson Cancer Center
- Myrna C. B. Godoy
- Department of Thoracic Imaging, the University of Texas MD Anderson Cancer Center
- Mara B. Antonoff
- Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center
- Boris Sepesi
- Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center
- Harvey I. Pass
- Department of Cardiothoracic Surgery, New York University Langone Medical Center
- Carmen Behrens
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Ara A. Vaporciyan
- Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center
- John V. Heymach
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Paul Scheet
- Department of Epidemiology, the University of Texas MD Anderson Cancer Center
- J. Jack Lee
- Department of Biostatistics, the University of Texas MD Anderson Cancer Center
- Jia Wu
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Alexandre Reuben
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Humam Kadara
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Ignacio I. Wistuba
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Jianjun Zhang
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-22890-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
The evolution of immune landscape in lung adenocarcinoma (ADC) is largely unknown. Here the authors use a cohort of resected invasive lung ADC and its precursors and show a gradual increase of immunosuppression and decrease of anti-tumor response associated with specific genomic and epigenetic features.
