Translational Medicine of Aging (Jan 2023)

Mitochondrial cardiomyopathy and emerging therapeutics

  • Jinjuan Yang,
  • Xiaoxian Zhang,
  • Meng Kou,
  • Boon Xuan Lian,
  • Zhixin Chiang,
  • Jace Chen,
  • Xiaoya Zhou,
  • Ziyue Li,
  • Jinqiu Zhang,
  • Xiao Su,
  • Qizhou Lian

Journal volume & issue
Vol. 7
pp. 98 – 108

Abstract

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Genetic mitochondrial cardiomyopathy (MCM) is a myocardial condition characterized by abnormal cardiac structure and function secondary to genetic defects. Severity can vary from asymptomatic to severe with manifestations that include heart failure, arrhythmias, and sudden cardiac death. The heterogeneity of gene mutation-provoked mitochondrial dysfunction and a variety of manifestations hamper the development of effective therapeutics. In this review, we present the common pathogenesis of mitochondrial cardiomyopathies, and the most recent promising novel therapeutic strategies for cardiac repair including use of cells or stem cells, adeno-associated virus (AAV)-based gene therapies, mitochondrial-based therapy, pharmaceutical compounds, dietary supplementation, and exercise. We discuss their respective advantages and limitations that may aid their broader clinical application. Some novel treatments remain a long way from achieving safe and effective clinical therapeutic effects.

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