P27 Prevalence of microvascular dysfunction in diabetic patients with normal gated spect

Abstract

Introduction: Patients with diabetes have an increased risk for cardiovascular events. Microvascular dysfunction is an early sign of damage, associated with poorer prognosis in these patients, including those with normal gated SPECT. Objective: The aim of this study was to assess the prevalence of microvascular dysfunction according to the type of diabetes through quantification of coronary flow reserve (CFR) in patients with normal gated SPECT. Materials and methods: Patients included in the study had diabetes without known history of coronary disease, without perfusión defects in c99-MIBI gated SPECT and preserved ventricular function. CFR was calculated by means of peak/resting coronary flow velocity ratio after dipyridamole with 4DM®-SPECT software with cadmium zinc telluride detectors (CZT-SPECT). CFR < 2 was considered to be microvascular dysfunction, and CFR < 1.6 was regarded as severe dysfunction.

Keywords

• disfunción microvascular
• diabetes tipo 1 y 2
• gated-spectnormal