A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance

Fangyuan Li; Heng Sun; Jiafeng Ren; Bo Zhang; Xi Hu; Chunyan Fang; Jiyoung Lee; Hongzhou Gu; Daishun Ling

doi:10.1038/s41467-022-35022-w

Nature Communications (Nov 2022)

A nuclease-mimetic platinum nanozyme induces concurrent DNA platination and oxidative cleavage to overcome cancer drug resistance

Fangyuan Li,
Heng Sun,
Jiafeng Ren,
Bo Zhang,
Xi Hu,
Chunyan Fang,
Jiyoung Lee,
Hongzhou Gu,
Daishun Ling

Affiliations

Fangyuan Li: Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University
Heng Sun: Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University
Jiafeng Ren: Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University
Bo Zhang: Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, National Center for Translational Medicine, Shanghai Jiao Tong University
Xi Hu: Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University
Chunyan Fang: Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province
Jiyoung Lee: Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University
Hongzhou Gu: Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province
Daishun Ling: Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University

DOI: https://doi.org/10.1038/s41467-022-35022-w
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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One of the mechanisms underlying platinum (Pt) resistance is the spontaneous nucleotide-excision repair of cancer cells. Here, nuclease-mimetic Pt nanozymes are targeted to the cancer cell nucleus and induce concurrent DNA platination and oxidative cleavage to overcome Pt resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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