Breakthroughs in the Roles of Interferon-stimulated Genes in Tumor Immunity

Abstract

Interferon-stimulated genes (ISGs) are crucially expressed in response to interferons and play pivotal roles in tumor immunity. These genes can either inhibit or promote tumor growth and infiltration by modulating immunosuppressive molecules, immune checkpoint inhibition, and immune editing. This review examines the specific mechanisms through which ISGs influence tumor immunity and their impact on oncological drugs, aiming to provide a theoretical foundation for developing more precise treatment strategies.

Keywords

• interferon-stimulated genes
• immune checkpoint inhibition
• immunosuppressive molecules
• oncological drugs