Open Source Tool for VH-replacement Products Discovery and Analysis

Abstract

In this project an open source tool for discovery and analysis of abnormal immunoglobulin genes rearrangements was developed. The main goal is in finding so-called “footprints” - small parts of incompletely rearranged V-segments in IGH genes. Joint usage of publicly available databases, on-line markup IMGT V-Quest and clonal families analyzer Partis allowed to prepare an informative dataset, which was processed via the developed tool. A few dependencies between patient phenotype and footprints statistics were discovered.

Keywords

• immunoinformatics
• VDJ recombination
• VH-replacement
• footprint