Frontiers in Cell and Developmental Biology (Jan 2024)
Mechanisms and otoprotective strategies of programmed cell death on aminoglycoside-induced ototoxicity
- Lei Han,
- Lei Han,
- Lei Han,
- Lei Han,
- Zijing Wang,
- Zijing Wang,
- Zijing Wang,
- Zijing Wang,
- Daqi Wang,
- Daqi Wang,
- Daqi Wang,
- Ziwen Gao,
- Ziwen Gao,
- Ziwen Gao,
- Shaowei Hu,
- Shaowei Hu,
- Shaowei Hu,
- Dazhi Shi,
- Yilai Shu,
- Yilai Shu,
- Yilai Shu,
- Yilai Shu
Affiliations
- Lei Han
- Department of Otorhinolaryngology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
- Lei Han
- ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
- Lei Han
- Institutes of Biomedical Sciences, Fudan University, Shanghai, China
- Lei Han
- NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China
- Zijing Wang
- Department of Otorhinolaryngology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
- Zijing Wang
- ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
- Zijing Wang
- Institutes of Biomedical Sciences, Fudan University, Shanghai, China
- Zijing Wang
- NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China
- Daqi Wang
- ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
- Daqi Wang
- Institutes of Biomedical Sciences, Fudan University, Shanghai, China
- Daqi Wang
- NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China
- Ziwen Gao
- ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
- Ziwen Gao
- Institutes of Biomedical Sciences, Fudan University, Shanghai, China
- Ziwen Gao
- NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China
- Shaowei Hu
- ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
- Shaowei Hu
- Institutes of Biomedical Sciences, Fudan University, Shanghai, China
- Shaowei Hu
- NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China
- Dazhi Shi
- Department of Otorhinolaryngology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
- Yilai Shu
- Department of Otorhinolaryngology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
- Yilai Shu
- ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China
- Yilai Shu
- Institutes of Biomedical Sciences, Fudan University, Shanghai, China
- Yilai Shu
- NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China
- DOI
- https://doi.org/10.3389/fcell.2023.1305433
- Journal volume & issue
-
Vol. 11
Abstract
Aminoglycosides are commonly used for the treatment of life-threatening bacterial infections, however, aminoglycosides may cause irreversible hearing loss with a long-term clinical therapy. The mechanism and prevention of the ototoxicity of aminoglycosides are still limited although amounts of studies explored widely. Specifically, advancements in programmed cell death (PCD) provide more new perspectives. This review summarizes the general signal pathways in programmed cell death, including apoptosis, autophagy, and ferroptosis, as well as the mechanisms of aminoglycoside-induced ototoxicity. Additionally, novel interventions, especially gene therapy strategies, are also investigated for the prevention or treatment of aminoglycoside-induced hearing loss with prospective clinical applications.
Keywords
