Nature Communications (Nov 2017)

Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

  • Tal Nuriel,
  • Sergio L. Angulo,
  • Usman Khan,
  • Archana Ashok,
  • Qiuying Chen,
  • Helen Y. Figueroa,
  • Sheina Emrani,
  • Li Liu,
  • Mathieu Herman,
  • Geoffrey Barrett,
  • Valerie Savage,
  • Luna Buitrago,
  • Efrain Cepeda-Prado,
  • Christine Fung,
  • Eliana Goldberg,
  • Steven S. Gross,
  • S. Abid Hussaini,
  • Herman Moreno,
  • Scott A. Small,
  • Karen E. Duff

DOI
https://doi.org/10.1038/s41467-017-01444-0
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

Read online

The APOE4 allele is the leading risk factor for late-onset Alzheimer’s disease, but how it might contribute to the disease is not clear. Here the authors show that a mouse expressing the human APOE4 allele displays hyperactivity in the entorhinal cortex due to a decreased inhibitory tone, which may in part explain accelerated Alzheimer’s pathology in APOE4 carriers.