Experimental Hematology & Oncology (Oct 2023)

Chinese expert consensus on Bruton tyrosine kinase inhibitors in the treatment of B-cell malignancies

  • Yuqin Song,
  • Shang-Ju Wu,
  • Zhixiang Shen,
  • Donglu Zhao,
  • Thomas Sau Yan Chan,
  • Huiqiang Huang,
  • Lugui Qiu,
  • Jianyong Li,
  • Tran-der Tan,
  • Jun Zhu,
  • Yongping Song,
  • Wei-Han Huang,
  • Weili Zhao,
  • Herman Sung Yu Liu,
  • Wei Xu,
  • Naizhi Chen,
  • Jun Ma,
  • Cheng-Shyong Chang,
  • Eric Wai Choi Tse

DOI
https://doi.org/10.1186/s40164-023-00448-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 26

Abstract

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Abstract Targeted therapy with Bruton tyrosine kinase (BTK) inhibitors have revolutionized the treatment of patients with various B-cell malignancies. BTK inhibitors such as ibrutinib, zanubrutinib, orelabrutinib, and acalabrutinib have shown good clinical efficacy and better safety profiles than those of traditional chemotherapy and chemoimmunotherapy regimens. Multiple studies on new BTK inhibitors are ongoing, which may provide more therapeutic options for the treatment of B-cell malignancies. Considering the unmet need of evidence on BTK inhibitors in all clinical settings and to standardize the use of BTK inhibitors available in mainland China, Taiwan, Hong Kong, and Macau regions, this consensus has been formulated for the treatment of various B-cell malignancies based on the clinical practice and available evidences on the use of BTK inhibitors. The recommendations of this consensus will provide guidance to physicians and clinical researchers on the effective treatment of B-cell malignancies with BTK inhibitors.

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