Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

Tyler M. Weaver; Timothy H. Click; Thu H. Khoang; M. Todd Washington; Pratul K. Agarwal; Bret D. Freudenthal

doi:10.1038/s41467-022-30577-0

Nature Communications (May 2022)

Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

Tyler M. Weaver,
Timothy H. Click,
Thu H. Khoang,
M. Todd Washington,
Pratul K. Agarwal,
Bret D. Freudenthal

Affiliations

Tyler M. Weaver: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center
Timothy H. Click: Department of Physiological Sciences and High-Performance Computing Center, Oklahoma State University
Thu H. Khoang: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center
M. Todd Washington: Department of Biochemistry and Molecular Biology, University of Iowa
Pratul K. Agarwal: Department of Physiological Sciences and High-Performance Computing Center, Oklahoma State University
Bret D. Freudenthal: Department of Biochemistry and Molecular Biology, University of Kansas Medical Center

DOI: https://doi.org/10.1038/s41467-022-30577-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Rev1 is a specialized translesion synthesis DNA polymerase involved in the bypass DNA damage during DNA replication. Here, the authors determine the structural basis for preferential incorporation of dCTP by Rev1 during bypass of DNA damage.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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