Cellular mechanisms of heterogeneity in NF2-mutant schwannoma

Christine Chiasson-MacKenzie; Jeremie Vitte; Ching-Hui Liu; Emily A. Wright; Elizabeth A. Flynn; Shannon L. Stott; Marco Giovannini; Andrea I. McClatchey

doi:10.1038/s41467-023-37226-0

Nature Communications (Mar 2023)

Cellular mechanisms of heterogeneity in NF2-mutant schwannoma

Christine Chiasson-MacKenzie,
Jeremie Vitte,
Ching-Hui Liu,
Emily A. Wright,
Elizabeth A. Flynn,
Shannon L. Stott,
Marco Giovannini,
Andrea I. McClatchey

Affiliations

Christine Chiasson-MacKenzie: Massachusetts General Hospital Cancer Center, Harvard Medical School
Jeremie Vitte: Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California Los Angeles
Ching-Hui Liu: Massachusetts General Hospital Cancer Center, Harvard Medical School
Emily A. Wright: Massachusetts General Hospital Cancer Center, Harvard Medical School
Elizabeth A. Flynn: Massachusetts General Hospital Cancer Center, Harvard Medical School
Shannon L. Stott: Massachusetts General Hospital Cancer Center, Harvard Medical School
Marco Giovannini: Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA and Jonsson Comprehensive Cancer Center (JCCC), University of California Los Angeles
Andrea I. McClatchey: Massachusetts General Hospital Cancer Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-023-37226-0
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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Schwannomas are mainly caused by NF2 tumour suppressor inactivation, but they display intratumoural heterogeneity. Here the authors show that this heterogeneity is caused by the loss of polarity and acquisition of different programmes of ErbB ligand production in NF2-mutant Schwann cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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