Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Xinxin Huang; Bin Guo; Sheng Liu; Jun Wan; Hal E. Broxmeyer

doi:10.1038/s41467-018-05178-5

Nature Communications (Jul 2018)

Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment

Xinxin Huang,
Bin Guo,
Sheng Liu,
Jun Wan,
Hal E. Broxmeyer

Affiliations

Xinxin Huang: Department of Microbiology and Immunology, Indiana University School of Medicine
Bin Guo: Department of Microbiology and Immunology, Indiana University School of Medicine
Sheng Liu: Department of Medical and Molecular Genetics, Indiana University School of Medicine
Jun Wan: Department of Medical and Molecular Genetics, Indiana University School of Medicine
Hal E. Broxmeyer: Department of Microbiology and Immunology, Indiana University School of Medicine

DOI: https://doi.org/10.1038/s41467-018-05178-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Enhancement of haematopoietic stem cell (HSC) homing and engraftment is critical for haematopoietic cell transplantation. Here, the authors find that HDAC5 inhibition enhances HSC homing and engraftment by increasing p65 acetylation and enhancing NF-kB mediated CXCR4 transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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