Diabetes, Metabolic Syndrome and Obesity (Feb 2024)

Strong Association of Metabolic Parameters with ADMA and VCAM-1 in Normo-Weight Subjects with Metabolic Syndrome

  • Rakhmat II,
  • Nugraha GI,
  • Ariyanto EF,
  • Pratiwi YS,
  • Linasari D,
  • Fatimah SN,
  • Ghozali M,
  • Syamsunarno MRA,
  • Akbar MR,
  • Achmad TH

Journal volume & issue
Vol. Volume 17
pp. 833 – 839

Abstract

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Iis Inayati Rakhmat,1– 3 Gaga Irawan Nugraha,3,4 Eko Fuji Ariyanto,3,4 Yuni Susanti Pratiwi,3,4 Desy Linasari,5 Siti Nur Fatimah,3,6 Mohammad Ghozali,3,4 Mas Rizky AA Syamsunarno,3,4 Mohammad Rizki Akbar,3,7 Tri Hanggono Achmad3,4 1Doctoral Study Program Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Biochemistry, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, West Java, Indonesia; 3Cardiometabolic Working Group Study, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 4Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 5Department of Community Medicine, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, West Java, Indonesia; 6Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 7Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Padjadjaran-Hasan Sadikin General Hospital, Bandung, West Java, IndonesiaCorrespondence: Gaga Irawan Nugraha, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Eycmann 38, Bandung, West Java, 40161, Indonesia, Tel/Fax +6222 2032170, Email [email protected]: Metabolic syndrome (MetS) is a risk factor for cardiovascular disease and is linked to obesity. Subjects with MetS who have normo-weight potentially show higher mortality and morbidity.Purpose: This study aims to reveal the critical essential metabolic parameters associated with endothelial dysfunction in MetS subjects with normo-weight compared to obese.Patients and Methods: The study was designed using a case–control approach. Ninety-nine MetS subjects (34 Normo-weight and 65 obese) from the urban population were enrolled in this study. The components of MetS are based on NCEP/ATP III criteria. Asymmetric dimethylarginine (ADMA) and vascular cell adhesion molecule 1 (VCAM-1) as markers for endothelial dysfunction were measured in both groups.Results: Fasting blood glucose (FBG) levels were higher in the normo-weight group (143.38 ± 79.8 mg/dL) compared to the obese group (120.89 ± 46.5 mg/dL). High-density lipoprotein cholesterol (HDL-c) levels in the normo-weight group were lower (42.82 ± 10.1 mg/dL) compared to obesity (45.74 ± 9.3 mg/dL), while triacylglycerol (TAG) levels were higher in the obese (197.25 ± 110.5 mg/dL) compared to the normo-weight group (167.03 ± 98.4 mg/dL), although the differences were statistically not significant (all p > 0.05). The difference between ADMA and VCAM-1 levels was statistically not significant in both groups. Correlation between MetS components with endothelial dysfunction parameters shows that metabolic parameters correlate strongly. Interestingly, a stronger correlation between FBG and ADMA was observed in normo-weight (r = 0.519) compared to obese groups (r = 0.445). In addition, TAG consistently shows a significant correlation with ADMA and VCAM-1 in normo-weight groups.Conclusion: Metabolic parameters, especially FBG and TAG, correlate strongly with endothelial dysfunction parameters in normo-weight subjects with metabolic syndrome.Keywords: ADMA, normal-weight metabolically unhealthy, VCAM-1

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