Communications Biology (Mar 2022)

Secretory quality control constrains functional selection-associated protein structure innovation

  • Bin Cheng,
  • Jian-Min Lv,
  • Yu-Lin Liang,
  • Li Zhu,
  • Xiao-Ping Huang,
  • Hai-Yun Li,
  • Lawrence A. Potempa,
  • Shang-Rong Ji,
  • Yi Wu

DOI
https://doi.org/10.1038/s42003-022-03220-3
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 10

Abstract

Read online

The mismatch in the conserved structure but different expression levels of C-reactive protein (CRP) in distinct species is reconciled by functional selection on hidden activities of unfolded CRPs.