Molbank
(May 2019)
Synthesis of 1<i>H</i>-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole and Evaluation of Its Antiprotozoal Activity
Jean Guillon,
Clotilde Boudot,
Anita Cohen,
Solène Savrimoutou,
Sandra Rubio,
Vittoria Milano,
Mathieu Marchivie,
Nadine Azas,
Catherine Mullié,
Pascal Sonnet,
Bertrand Courtioux
Affiliations
Jean Guillon
Laboratoire ARNA, INSERM U1212/UMR CNRS 5320, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, France
Clotilde Boudot
INSERM U1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology, Université de Limoges, F-87025 Limoges, France
Anita Cohen
IHU Méditerranée Infection, UMR VITROME, Aix-Marseille Univ., 19-21 Boulevard Jean Moulin, 13005 Marseille, France
Solène Savrimoutou
Laboratoire ARNA, INSERM U1212/UMR CNRS 5320, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, France
Sandra Rubio
Laboratoire ARNA, INSERM U1212/UMR CNRS 5320, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, France
Vittoria Milano
Laboratoire ARNA, INSERM U1212/UMR CNRS 5320, UFR des Sciences Pharmaceutiques, Univ. Bordeaux, 146 rue Léo Saignat, F-33076 Bordeaux CEDEX, France
Mathieu Marchivie
ISM-CNRS UMR 5255, Univ. Bordeaux, F-33405 Talence CEDEX, France
Nadine Azas
IHU Méditerranée Infection, UMR VITROME, Aix-Marseille Univ., 19-21 Boulevard Jean Moulin, 13005 Marseille, France
Catherine Mullié
AGIR (Agents Infectieux, Résistance et chimiothérapie), EA 4294, UFR de Pharmacie, Université de Picardie Jules Verne, F-80037 Amiens, France
Pascal Sonnet
AGIR (Agents Infectieux, Résistance et chimiothérapie), EA 4294, UFR de Pharmacie, Université de Picardie Jules Verne, F-80037 Amiens, France
Bertrand Courtioux
INSERM U1094, Tropical Neuroepidemiology, Institute of Neuroepidemiology and Tropical Neurology, Université de Limoges, F-87025 Limoges, France
DOI
https://doi.org/10.3390/M1060
Journal volume & issue
Vol. 2019,
no. 2
p.
M1060
Abstract
Read online
1H-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole was synthesized via a multi-step pathway starting from 2-iodoaniline. Structure characterization of this new indole compound was achieved by 1H-NMR, 13C-NMR and ESI-MS spectral analysis. The title compound was screened in vitro against three protozoan parasites (Plasmodium falciparum, Leishmania donovani and Trypanosoma brucei brucei). Biological results showed antiparasitic activity with IC50 values in the μM range.
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