The Effect of Probiotic Administration on the Level of Interleukin-6 and Interleukin-10 in Opioids Poisoned Patients Admitted to the Intensive Care Unit

Abstract

Introduction: Recent research has revealed that exposure to toxins and substances like cannabis, opium, heroin, and tramadol can inhibit the growth of lymphocytes. One of the key factors identified is the impact of probiotics on decreasing and managing inflammation in individuals affected by poisoning. This study examined the impact of probiotic treatment on interleukin-6 (IL-6) and IL-10 levels in opioid-poisoned patients. Methods: This randomized clinical trial included 70 patients with opioid poisoning who were admitted to the poisoned intensive care unit for 6 months. Patients were randomly assigned to two intervention groups that received oral probiotics or a control group that received placebo. Data collected were analyzed using IBM SPSS version 22 software. Results: The intervention group had methadone (28.6%) and tramadol as the most common causes of poisoning, whereas the control group had tramadol (45.7%) and methadone (28.6%). There was a noticeable decrease in Acute Physiology and Chronic Health Evaluation scores in the intervention group before and after the intervention, whereas no significant difference was observed in the control group. Significantly, the levels of IL-6 and IL-10 were lower in the probiotic group than in the control group. Conclusion: Probiotic use improved the condition of patients and decreased IL-6 and IL-10. This shows the positive effect of probiotics as an adjunctive treatment in opioid-poisoned patients, improving the condition of the patients’ immune system.

Keywords

• immune system
• interleukins-6
• interleukins-10
• opioid
• probiotics
• poisoning