Cytotoxic effect of bionanocatalysts evaluated by diffuse reflectance spectroscopy in an in vivo model of hepatocellular carcinoma

Abstract

Given the absence of effective and selective treatments for hepatocellular carcinoma (HCC), the antitumor effect of novel bionanocatalysts was evaluated in two different tissues (liver and lung) of a rat model with HCC using Diffuse Reflectance Spectroscopy. The spectra obtained showed a significant decrease in signal intensity in the presence of tumor tissues with respect to healthy tissue. An increase in signal intensity was observed in diseased rats treated with bionanocatalysts, suggesting their antitumor effect in terms of tumor tissue reduction with respect to the diseased control.

Keywords

• Bionanocatalysts
• Cytotoxicity
• Diffuse reflectance spectroscopy
• Hepatocellular carcinoma