EXPERIENCE OF METHOTREXATE USE IN A PATIENT WITH SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS

Abstract

The article presents a case of early onset of systemic juvenile arthritis with active articular syndrome, severe systemic manifestations and high level of laboratory disease activity indicators. It describes successful use of methotrexate for intramuscular administration in the dose of 25 mg/m2 of body surface per week. Systemic disease manifestations terminated in a child after 1 month of treatment, acute inflammatory articular alterations, arthralgiae and morning stiffness disappeared and laboratory disease activity indicators reduced after 6 months; range of motions completely recovered in 4 out of 6 affected joints after 12 months of treatment. Inactive disease state and remission were registered after 6 and 12 months of treatment, respectively. Remission has been present for 24 months.

Keywords

• children
• systemic juvenile idiopathic arthritis
• methotrexate
• intramuscular administration