Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening

Abstract

Key points Benzoxaborole Compound Tavaborole was discovered against E. coli by using HTS. Tavaborole showed synergistic efficacy with aminoglycosides in vitro and in vivo. The main mechanism of synergy was promoting protein mistranslation mutually.

Keywords

• Drug repurposing
• Microbial proteomics
• Benzoxaborole
• Drug resistance
• Uropathogenic Escherichia col