Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening

Shasha Liu; Pengfei She; Zehao Li; Yimin Li; Linhui Li; Yifan Yang; Linying Zhou; Yong Wu

doi:10.1186/s13568-022-01488-6

AMB Express (Dec 2022)

Drug synergy discovery of tavaborole and aminoglycosides against Escherichia coli using high throughput screening

Shasha Liu,
Pengfei She,
Zehao Li,
Yimin Li,
Linhui Li,
Yifan Yang,
Linying Zhou,
Yong Wu

Affiliations

Shasha Liu: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Pengfei She: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Zehao Li: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Yimin Li: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Linhui Li: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Yifan Yang: Department of Laboratory Medicine, The Third Xiangya Hospital, Central South University
Linying Zhou: Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University
Yong Wu: Department of Laboratory Medicine, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University

DOI: https://doi.org/10.1186/s13568-022-01488-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Key points Benzoxaborole Compound Tavaborole was discovered against E. coli by using HTS. Tavaborole showed synergistic efficacy with aminoglycosides in vitro and in vivo. The main mechanism of synergy was promoting protein mistranslation mutually.

Published in AMB Express

ISSN: 2191-0855 (Online)
Publisher: SpringerOpen
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Biotechnology; Science: Microbiology
Website: http://www.amb-express.com/

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Abstract

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