Communications Biology (Jun 2021)
The genetic architecture of age-related hearing impairment revealed by genome-wide association analysis
- Erna V. Ivarsdottir,
- Hilma Holm,
- Stefania Benonisdottir,
- Thorhildur Olafsdottir,
- Gardar Sveinbjornsson,
- Gudmar Thorleifsson,
- Hannes P. Eggertsson,
- Gisli H. Halldorsson,
- Kristjan E. Hjorleifsson,
- Pall Melsted,
- Arnaldur Gylfason,
- Gudny A. Arnadottir,
- Asmundur Oddsson,
- Brynjar O. Jensson,
- Aslaug Jonasdottir,
- Adalbjorg Jonasdottir,
- Thorhildur Juliusdottir,
- Lilja Stefansdottir,
- Vinicius Tragante,
- Bjarni V. Halldorsson,
- Hannes Petersen,
- Gudmundur Thorgeirsson,
- Unnur Thorsteinsdottir,
- Patrick Sulem,
- Ingibjorg Hinriksdottir,
- Ingileif Jonsdottir,
- Daniel F. Gudbjartsson,
- Kari Stefansson
Affiliations
- Erna V. Ivarsdottir
- deCODE Genetics/Amgen
- Hilma Holm
- deCODE Genetics/Amgen
- Stefania Benonisdottir
- deCODE Genetics/Amgen
- Thorhildur Olafsdottir
- deCODE Genetics/Amgen
- Gardar Sveinbjornsson
- deCODE Genetics/Amgen
- Gudmar Thorleifsson
- deCODE Genetics/Amgen
- Hannes P. Eggertsson
- deCODE Genetics/Amgen
- Gisli H. Halldorsson
- deCODE Genetics/Amgen
- Kristjan E. Hjorleifsson
- deCODE Genetics/Amgen
- Pall Melsted
- deCODE Genetics/Amgen
- Arnaldur Gylfason
- deCODE Genetics/Amgen
- Gudny A. Arnadottir
- deCODE Genetics/Amgen
- Asmundur Oddsson
- deCODE Genetics/Amgen
- Brynjar O. Jensson
- deCODE Genetics/Amgen
- Aslaug Jonasdottir
- deCODE Genetics/Amgen
- Adalbjorg Jonasdottir
- deCODE Genetics/Amgen
- Thorhildur Juliusdottir
- deCODE Genetics/Amgen
- Lilja Stefansdottir
- deCODE Genetics/Amgen
- Vinicius Tragante
- deCODE Genetics/Amgen
- Bjarni V. Halldorsson
- deCODE Genetics/Amgen
- Hannes Petersen
- Faculty of Medicine, School of Health Sciences, University of Iceland
- Gudmundur Thorgeirsson
- deCODE Genetics/Amgen
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen
- Patrick Sulem
- deCODE Genetics/Amgen
- Ingibjorg Hinriksdottir
- National Institute of Hearing and Speech in Iceland
- Ingileif Jonsdottir
- deCODE Genetics/Amgen
- Daniel F. Gudbjartsson
- deCODE Genetics/Amgen
- Kari Stefansson
- deCODE Genetics/Amgen
- DOI
- https://doi.org/10.1038/s42003-021-02224-9
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 13
Abstract
Erna Ivarsdottir et al. report a genome-wide association meta-analysis for age-related hearing loss in the Icelandic and UK populations. They identify 21 novel variants, 13 of which are rare, and reveal a genetic correlation between age-related hearing loss and tinnitus.
