Pulmonary carcinoid tumour with remarkably high levels of pro-gastrin-releasing peptide: A case report

Natsuki Nakagawa; Masanori Kawakami; Masaki Suzuki; Satoshi Noguchi; Akihisa Mitani; Goh Tanaka; Aya Shinozaki-Ushiku; Takahide Nagase

Respiratory Medicine Case Reports (Jan 2023)

Pulmonary carcinoid tumour with remarkably high levels of pro-gastrin-releasing peptide: A case report

Natsuki Nakagawa,
Masanori Kawakami,
Masaki Suzuki,
Satoshi Noguchi,
Akihisa Mitani,
Goh Tanaka,
Aya Shinozaki-Ushiku,
Takahide Nagase

Affiliations

Natsuki Nakagawa: Department of Respiratory Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan
Masanori Kawakami: Department of Respiratory Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan; Corresponding author. Department of Respiratory Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Masaki Suzuki: Department of Pathology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan
Satoshi Noguchi: Department of Respiratory Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan
Akihisa Mitani: Department of Respiratory Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan
Goh Tanaka: Department of Respiratory Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan
Aya Shinozaki-Ushiku: Department of Pathology, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan
Takahide Nagase: Department of Respiratory Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, 113-8655, Japan

Journal volume & issue: Vol. 43
p. 101836

Abstract

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An 86-year-old woman presented with chronic cough and chest pain. Computed tomography revealed two masses in the right lower lobe of the lung accompanied by multiple lymphadenopathies and metastasis to the rib. The pro-gastrin-releasing peptide (ProGRP) levels were notably elevated (888 pg/mL). Based on these findings, our initial clinical diagnosis was small-cell lung cancer. However, the pathological diagnosis turned out to be an atypical carcinoid. The patient was finally treated with everolimus. Clinicians should be aware that carcinoid tumours are sometimes difficult to distinguish from small-cell lung cancer with respect to high ProGRP levels and multiple metastases.

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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