Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case–Control Study
Aikaterini Kyriakopoulou,
Kyriakos Samikos,
Aikaterini Kanavaki,
Efthymia Alexopoulou,
Maria Argyropoulou,
Theodora Psaltopoulou,
Christina Kanaka-Gantenbein,
Argyrios Dinopoulos,
Melpomene Giorgi,
Anastasia Antoniadou,
Iliani Filippa,
Nikolaos Siafakas,
Stylianos Serghiou,
Vassiliki Papaevangelou
Affiliations
Aikaterini Kyriakopoulou
Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Kyriakos Samikos
Iaso Maternity Hospital, 151 23 Athens, Greece
Aikaterini Kanavaki
Iaso Maternity Hospital, 151 23 Athens, Greece
Efthymia Alexopoulou
2nd Department of Radiology, General University Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Maria Argyropoulou
Department of Radiology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 455 00 Ioannina, Greece
Theodora Psaltopoulou
Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece
Christina Kanaka-Gantenbein
Diabetes Center, Division of Endocrinology, Diabetes, and Metabolism, First Department of Pediatrics, Agia Sophia Children’s Hospital, National and Kapodistrian University of Athens, 115 27 Athens, Greece
Argyrios Dinopoulos
Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Melpomene Giorgi
Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Anastasia Antoniadou
Fourth Department of Medicine, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Iliani Filippa
Iaso Maternity Hospital, 151 23 Athens, Greece
Nikolaos Siafakas
Clinical Microbiology Laboratory, Attikon General University Hospital, 124 62 Athens, Greece
Stylianos Serghiou
Prolaio, Inc., Chicago, IL 60606, USA
Vassiliki Papaevangelou
Third Department of Pediatrics, Attikon General University Hospital, National and Kapodistrian University of Athens, 124 62 Athens, Greece
Objective: To investigate the clinical characteristics associated with the presence of LSV at birth. Design: Prospective 1:1 case–control study. Setting: Two tertiary neonatal units in Athens, Greece. Patients: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected. Main outcome measure: Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided p-values were computed using the likelihood ratio test. Results: This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV. Conclusions: This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV’s pathophysiological mechanisms.
