Chondrogenesis in the synovial tissue is associated with the onset of pseudogout after total knee arthroplasty

Ryosuke Sato, MD; Shunji Nakano, MD, PhD; Tomoya Takasago, MD; Masaru Nakamura, MD; Masahiro Kashima, MD; Takashi Chikawa, MD, PhD; Daisuke Hamada, MD, PhD; Tomohiro Goto, MD, PhD; Koichi Sairyo, MD, PhD

doi:10.1016/j.artd.2015.10.007

Arthroplasty Today (Sep 2016)

Chondrogenesis in the synovial tissue is associated with the onset of pseudogout after total knee arthroplasty

Ryosuke Sato, MD,
Shunji Nakano, MD, PhD,
Tomoya Takasago, MD,
Masaru Nakamura, MD,
Masahiro Kashima, MD,
Takashi Chikawa, MD, PhD,
Daisuke Hamada, MD, PhD,
Tomohiro Goto, MD, PhD,
Koichi Sairyo, MD, PhD

Affiliations

Ryosuke Sato, MD: Department of Orthopedics, Tokushima Municipal Hospital, Tokushima, Japan
Shunji Nakano, MD, PhD: Department of Orthopedics, Tokushima Municipal Hospital, Tokushima, Japan
Tomoya Takasago, MD: Department of Orthopedics, Tokushima Municipal Hospital, Tokushima, Japan
Masaru Nakamura, MD: Department of Orthopedics, Tokushima Municipal Hospital, Tokushima, Japan
Masahiro Kashima, MD: Department of Orthopedics, Tokushima Municipal Hospital, Tokushima, Japan
Takashi Chikawa, MD, PhD: Department of Orthopedics, Tokushima Municipal Hospital, Tokushima, Japan
Daisuke Hamada, MD, PhD: Department of Orthopedics, Institute of Biomedical sciences, Tokushima University Graduate School, Tokushima, Japan
Tomohiro Goto, MD, PhD: Department of Orthopedics, Institute of Biomedical sciences, Tokushima University Graduate School, Tokushima, Japan
Koichi Sairyo, MD, PhD: Department of Orthopedics, Institute of Biomedical sciences, Tokushima University Graduate School, Tokushima, Japan

DOI: https://doi.org/10.1016/j.artd.2015.10.007
Journal volume & issue: Vol. 2, no. 3
pp. 101 – 104

Abstract

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Postoperative pseudogout after total knee arthroplasty (TKA) is very rare, and its physical findings are very similar to infectious symptoms. In pseudogout, the mechanism underlying the deposition of calcium pyrophosphate dehydrate crystals remains unclear. Here, we report the histologic findings in a pseudogout attack in the late postoperative period after TKA. She had acute onset of arthritis of the knee 2 years after TKA. Histologic examination showed significant neutrophil infiltration. Interestingly, chondrogenesis was noted in the synovial tissue, and calcium pyrophosphate dehydrate crystals were synthesized mainly at the site of chondrogenesis, suggesting a potential mechanism underlying the occurrence of pseudogout after TKA.

Published in Arthroplasty Today

ISSN: 2352-3441 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Surgery: Orthopedic surgery
Website: https://www.journals.elsevier.com/arthroplasty-today/

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