Baculovirus Display of Peptides and Proteins for Medical Applications
Aaron Pavel Rodríguez-Hernández,
Daniel Martínez-Flores,
Adolfo Cruz-Reséndiz,
Teresa Padilla-Flores,
Rodrigo González-Flores,
Kenia Estrada,
Alicia Sampieri,
Aldo Román Camacho-Zarco,
Luis Vaca
Affiliations
Aaron Pavel Rodríguez-Hernández
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Daniel Martínez-Flores
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Adolfo Cruz-Reséndiz
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Teresa Padilla-Flores
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Rodrigo González-Flores
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Kenia Estrada
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Alicia Sampieri
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Aldo Román Camacho-Zarco
European Molecular Biology Laboratory, Grenoble Outstation, EMBL Grenoble, CEDEX 9, 38042 Grenoble, France
Luis Vaca
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City 04510, Mexico
Baculoviridae is a large family of arthropod-infective viruses. Recombinant baculoviruses have many applications, the best known is as a system for large scale protein production in combination with insect cell cultures. More recently recombinant baculoviruses have been utilized for the display of proteins of interest with applications in medicine. In the present review we analyze the different strategies for the display of proteins and peptides on the surface of recombinant baculoviruses and provide some examples of the different proteins displayed. We analyze briefly the commercially available systems for recombinant baculovirus production and display and discuss the future of this emerging and powerful technology.
