Co-transmission of acetylcholine and GABA regulates hippocampal states

Virág T. Takács; Csaba Cserép; Dániel Schlingloff; Balázs Pósfai; András Szőnyi; Katalin E. Sos; Zsuzsanna Környei; Ádám Dénes; Attila I. Gulyás; Tamás F. Freund; Gábor Nyiri

doi:10.1038/s41467-018-05136-1

Nature Communications (Jul 2018)

Co-transmission of acetylcholine and GABA regulates hippocampal states

Virág T. Takács,
Csaba Cserép,
Dániel Schlingloff,
Balázs Pósfai,
András Szőnyi,
Katalin E. Sos,
Zsuzsanna Környei,
Ádám Dénes,
Attila I. Gulyás,
Tamás F. Freund,
Gábor Nyiri

Affiliations

Virág T. Takács: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Csaba Cserép: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Dániel Schlingloff: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Balázs Pósfai: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
András Szőnyi: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Katalin E. Sos: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Zsuzsanna Környei: Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Ádám Dénes: Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Attila I. Gulyás: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Tamás F. Freund: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43
Gábor Nyiri: Laboratory of Cerebral Cortex Research Institute of Experimental Medicine, Hungarian Academy of Sciences, Szigony u 43

DOI: https://doi.org/10.1038/s41467-018-05136-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Acetylcholine (ACh) release in the central nervous system is thought to be unitary and mediated non-synaptically in volume transmission. Here, Takács and colleagues show cholinergic terminals juxtapose GABAergic synapses anatomically and functionally, and GABA and ACh molecules are co-transmitted.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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