OSOBENNOSTI METABOLIZMA KOSTNOY TKANI U BOL'NYKh ANKILOZIRUYuShchIM SPONDILOARTRITOM

Abstract

Objective: To define the specific features of bone metabolism and to estimate bone mineral density (BMD) in patients with ankylosing spondylitis (AS) Subjects and methods: Seventy-two patients (66 males and 6 females) with SA were examined. Markers of bone metabolism markers were assessed, by measuring the serum levels of osteocalcin (OC) and C-terminal telopeptides (bCrosslaps) by enzyme-linked immunoassay. Bone mineral density (BMD) was studied by distal forearm by dual-energy X-ray absorptiometry (DEXA) on a DexaScan DX-10 apparatus. BMD was estimated in women and men older 50 years by the T-test and in men under 50 years by the Z-test. Results: Low BMD was found by DEXA in 55% patients with SA., 7% patients had a vertebral fracture. The level of bCrosslaps was 0.52±0.37 ng/ml (p>0.05) and that of osteocalcin was 12,9±7,1 ng/ml (p<0.05), which is accordingly higher and lower than the reference values. With higher SA activity and advance of X-ray disease stage, there was a tendency for bCrosslaps to increase and osteocalcin to decrease. Correlation analysis revealed a correlation between the value of BMD and the SA activity, between the levels of OC and X-ray disease stage and functional index BASDAI., between the levels of bCrosslaps and degree of activity AS. Age and low physical activity also affected the parameters of BMD in patients with SA.

Keywords

• анкилозирующий спондилоартрит
• остеопороз
• маркеры косного метаболизма