Journal of Inflammation Research (Aug 2023)

Advanced Lung Cancer Inflammation Index for Predicting Prognostic Risk for Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

  • Wang X,
  • Wei C,
  • Fan W,
  • Sun L,
  • Zhang Y,
  • Sun Q,
  • Liu Y,
  • Liu J

Journal volume & issue
Vol. Volume 16
pp. 3631 – 3641

Abstract

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Xinchen Wang,1 Chen Wei,1 Wenjun Fan,1 Lixian Sun,1 Ying Zhang,1 Qiyu Sun,2 Yixiang Liu,1 Jingyi Liu1 1Department of Cardiology, The Affiliated Hospital of Chengde Medical University, The Chengde Institute of Cardiovascular Diseases, Chengde, Hebei, 067000, People’s Republic of China; 2Department of Clinical Laboratory, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of ChinaCorrespondence: Lixian Sun, Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, 067000, People’s Republic of China, Tel +86 314 227 9016, Fax +86 314 227 4895, Email [email protected]: The decreased advanced lung cancer inflammation index (ALI), defined as body mass index (BMI) * albumin (Alb)/neutrophil-to-lymphocyte ratio (NLR), is an independent prognostic risk factor for overall survival in gastric, lung, and colorectal cancers. This study aimed to investigate the value of ALI in predicting the risk of major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS).Patients and Methods: A total of 1624 patients with ACS undergoing percutaneous coronary intervention (PCI) were consecutively enrolled between January 2016 and December 2018. Follow-up data were collected at 1, 3, 6, and 12 months and annually thereafter. The primary endpoints were MACEs. All endpoints were defined as all-cause mortality, recurrent angina pectoris, restenosis/intra stent thrombosis, stroke, heart failure, and all-cause bleeding.Results: The MACEs group and non-MACEs group showed significant differences in patients with age > 65 years (28 [50.0%] vs 319 [23.7%]), history of heart failure (16 [28.6%] vs 127 [9.4%]), history of ischemic stroke (14 [25.0%] vs 186 [13.8%]), history of cardiogenic shock (6 [10.71%] vs 16 [1.19%]), left ventricular ejection fraction < 40% (8 [14.29%] vs 33 [2.46%]), and ALI < 343.96 (44 [78.65%] vs 680 [50.60%]) (all p< 0.001). The optimal cut-off value for ALI was 334.96. The area under the curve (AUC) of the 1-, 2-, 3-, and 5-year was 0.560, 0.577, 0.665, and 0.749, respectively. The survival rate was significantly lower in the low ALI group than in the high ALI group (log-rank p< 0.001). Low ALI was an independent risk factor for the long-term prognosis of patients with ACS after PCI, univariate HR: 3.671, 95% CI: 1.938– 6.953, p< 0.001; multivariate HR: 3.009, 95% CI: 1.57– 5.769, p=0.001.Conclusion: ALI score less than 334.96 is an independent prognostic risk factor for patients with ACS undergoing PCI and may be a novel marker for clinical practice.Keywords: acute coronary syndrome, advanced lung cancer inflammation index, prognosis, percutaneous coronary intervention

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