Frontiers in Oncology (Oct 2020)

Risk Stratification in Acute Myeloid Leukemia Using CXCR Gene Signatures: A Bioinformatics Analysis

  • Cong Lu,
  • Cong Lu,
  • Cong Lu,
  • Jiang Zhu,
  • Jiang Zhu,
  • Jiang Zhu,
  • Xiangjun Chen,
  • Xiangjun Chen,
  • Xiangjun Chen,
  • Yanjie Hu,
  • Yanjie Hu,
  • Yanjie Hu,
  • Wei Xie,
  • Wei Xie,
  • Wei Xie,
  • Junxia Yao,
  • Junxia Yao,
  • Junxia Yao,
  • Shiang Huang,
  • Shiang Huang,
  • Shiang Huang

DOI
https://doi.org/10.3389/fonc.2020.584766
Journal volume & issue
Vol. 10

Abstract

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The role of CXC chemokine receptors in tumors has been an increasingly researched focus in recent years. However, significant prognostic values of CXCR members in acute myeloid leukemia are yet to be explored profoundly. In this study, we firstly made an analysis of the relationship of CXCR family members and AML using samples from TCGA. Our results suggested that transcriptional expressions of CXCRs serve an important role in AML. CXCR transcript expressions, except CXCR1 expression, were significantly increased in AML. It displayed the expression pattern of CXCR members in different AML subtypes according to FAB classification. The correlations of CXCR transcript expression with different genotypes and karyotypes were also present. High CXCR2 expression was found to have a significantly worse prognosis compared with that of low CXCR2 expression, and CXCR2 was also found to be an independent prognostic factor. We also established a CXCR signature to identify high-risk subgroups of patients with AML. It was an independent prognostic factor and could become a powerful method to predict the survival rate of patients.

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