Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays

Martin Thunemann; Yichen Lu; Xin Liu; Kıvılcım Kılıç; Michèle Desjardins; Matthieu Vandenberghe; Sanaz Sadegh; Payam A. Saisan; Qun Cheng; Kimberly L. Weldy; Hongming Lyu; Srdjan Djurovic; Ole A. Andreassen; Anders M. Dale; Anna Devor; Duygu Kuzum

doi:10.1038/s41467-018-04457-5

Nature Communications (May 2018)

Deep 2-photon imaging and artifact-free optogenetics through transparent graphene microelectrode arrays

Martin Thunemann,
Yichen Lu,
Xin Liu,
Kıvılcım Kılıç,
Michèle Desjardins,
Matthieu Vandenberghe,
Sanaz Sadegh,
Payam A. Saisan,
Qun Cheng,
Kimberly L. Weldy,
Hongming Lyu,
Srdjan Djurovic,
Ole A. Andreassen,
Anders M. Dale,
Anna Devor,
Duygu Kuzum

Affiliations

Martin Thunemann: Department of Radiology, UCSD
Yichen Lu: Department of Electrical and Computer Engineering, UCSD
Xin Liu: Department of Electrical and Computer Engineering, UCSD
Kıvılcım Kılıç: Department of Neurosciences, UCSD
Michèle Desjardins: Department of Radiology, UCSD
Matthieu Vandenberghe: Department of Radiology, UCSD
Sanaz Sadegh: Department of Neurosciences, UCSD
Payam A. Saisan: Department of Neurosciences, UCSD
Qun Cheng: Department of Neurosciences, UCSD
Kimberly L. Weldy: Department of Neurosciences, UCSD
Hongming Lyu: Department of Electrical and Computer Engineering, UCSD
Srdjan Djurovic: Department of Medical Genetics, Oslo University Hospital
Ole A. Andreassen: NORMENT - KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo
Anders M. Dale: Department of Radiology, UCSD
Anna Devor: Department of Radiology, UCSD
Duygu Kuzum: Department of Electrical and Computer Engineering, UCSD

DOI: https://doi.org/10.1038/s41467-018-04457-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Optical imaging and manipulation technologies cannot be easily integrated with electrical recordings due to generation of light-induced artifacts. Here the authors report the optimization of transparent graphene microelectrode fabrication to achieve artifact-free electrical recordings along with deep 2-photon imaging in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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