Malignant Ovarian Steroid Cell Tumor Causing Severe Hyperandrogenism: Case Report And Review Of The Literature

Omalkhaire M. Alshaikh, MD; Stephane Laframboise, MD; Sylvia L. Asa, MD, PhD; Blaise Clarke, MD, MSc; Ozgur Mete, MD; Shereen Ezzat, MD

AACE Clinical Case Reports (Jan 2017)

Malignant Ovarian Steroid Cell Tumor Causing Severe Hyperandrogenism: Case Report And Review Of The Literature

Omalkhaire M. Alshaikh, MD,
Stephane Laframboise, MD,
Sylvia L. Asa, MD, PhD,
Blaise Clarke, MD, MSc,
Ozgur Mete, MD,
Shereen Ezzat, MD

Affiliations

Omalkhaire M. Alshaikh, MD: From the 1Department of Internal Medicine, Al-Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia; Departments of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Stephane Laframboise, MD: Gynecologic Oncology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Sylvia L. Asa, MD, PhD: Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Blaise Clarke, MD, MSc: Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Ozgur Mete, MD: Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Shereen Ezzat, MD: Departments of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.; Address correspondence to Dr. S. Ezzat, Princess Margaret Cancer Centre, University Health Network, 610 University Avenue, Room 7-327, Toronto, Ontario, M5G 2M9 Canada.

Journal volume & issue: Vol. 3, no. 3
pp. e269 – e274

Abstract

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ABSTRACT: Objective: To report a rare case of malignant ovarian steroid cell tumor with androgen excess.Methods: We describe the clinical presentation and management of a malignant ovarian steroid tumor with severe hyperandrogenism in a postmenopausal woman.Results: An 83-year-old patient had a 6-year history of features of androgen excess. Biochemistry confirmed elevated testosterone and dehydroepiandrosterone sulfate; investigations identified a 4.5-cm adnexal mass that was resected, and the histopathology diagnosis was a malignant steroid cell tumor. Eight months later, disease recurrence prompted a second surgical intervention, and a 3.5-cm mass adherent to the right pelvic sidewall was removed. The patient was not able to tolerate mitotane due to severe side effects. Eighteen months later, the disease relapsed with recurrence of clinical and biochemical features of androgen excess.Conclusion: This case illustrates the challenges of diagnosis and management of malignant ovarian steroid cell tumors.Abbreviations: CT computed tomography; DHEAS dehydroepiandrosterone sulfate; GnRH gonadotropin-releasing hormone; MRI magnetic resonance imaging; SCT steroid cell tumor

Published in AACE Clinical Case Reports

ISSN: 2376-0605 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.journals.elsevier.com/aace-clinical-case-reports

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