Nature Communications (Dec 2022)

Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes

  • Yosuke Ito,
  • Yuhei Chadani,
  • Tatsuya Niwa,
  • Ayako Yamakawa,
  • Kodai Machida,
  • Hiroaki Imataka,
  • Hideki Taguchi

DOI
https://doi.org/10.1038/s41467-022-35156-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 16

Abstract

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Here the authors find that nascent chains enriched in acidic amino acids destabilize the translating ribosome, eventually leading to stochastic premature termination in eukaryotes as in bacteria. Such risk of premature termination influences the amino acid distribution in the proteomes.