Nature Communications (Sep 2020)
Relative configuration of micrograms of natural compounds using proton residual chemical shift anisotropy
Abstract
Determination of 3D molecular structures remains challenging for natural products or organic compounds available in minute amounts. Here, the authors determine the structure of complex molecules, including few micrograms of briarane B-3 isolated from Briareum asbestinums, through measurement of 1H residual chemical shift anisotropy.