Crystal structure of an archaeal CorB magnesium transporter

Yu Seby Chen; Guennadi Kozlov; Brandon E. Moeller; Ahmed Rohaim; Rayan Fakih; Benoît Roux; John E. Burke; Kalle Gehring

doi:10.1038/s41467-021-24282-7

Nature Communications (Jun 2021)

Crystal structure of an archaeal CorB magnesium transporter

Yu Seby Chen,
Guennadi Kozlov,
Brandon E. Moeller,
Ahmed Rohaim,
Rayan Fakih,
Benoît Roux,
John E. Burke,
Kalle Gehring

Affiliations

Yu Seby Chen: Department of Biochemistry & Centre de Recherche en Biologie Structurale, McGill University
Guennadi Kozlov: Department of Biochemistry & Centre de Recherche en Biologie Structurale, McGill University
Brandon E. Moeller: Department of Biochemistry and Microbiology, University of Victoria
Ahmed Rohaim: Department of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science
Rayan Fakih: Department of Biochemistry & Centre de Recherche en Biologie Structurale, McGill University
Benoît Roux: Department of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science
John E. Burke: Department of Biochemistry and Microbiology, University of Victoria
Kalle Gehring: Department of Biochemistry & Centre de Recherche en Biologie Structurale, McGill University

DOI: https://doi.org/10.1038/s41467-021-24282-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 14

Abstract

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CNNM/CorB proteins are a conserved family of membrane proteins associated with Mg2+ transport. Here, structures of an archaeal CorB protein in apo state and with Mg2+-ATP bound and accompanying biophysical experiments suggest direct Mg2+ transport by CorB proteins.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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