Nature Communications (May 2021)

3D mechanical characterization of single cells and small organisms using acoustic manipulation and force microscopy

  • Nino F. Läubli,
  • Jan T. Burri,
  • Julian Marquard,
  • Hannes Vogler,
  • Gabriella Mosca,
  • Nadia Vertti-Quintero,
  • Naveen Shamsudhin,
  • Andrew deMello,
  • Ueli Grossniklaus,
  • Daniel Ahmed,
  • Bradley J. Nelson

DOI
https://doi.org/10.1038/s41467-021-22718-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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It is currently challenging to mechanically assess 3D specimens without manual handling. Here the authors combine a micro-force sensor and an acoustically controlled manipulation device to enable rotation of samples while assessing mechanical properties at the chosen region.